I love it because it helps to enhance my mood! Thanks to SAM-e, I feel a lot more cheerful and energetic than before! If you have mood or depression issues then definitely go for it!

Doctor's Best SAMe Review

Doctor's Best SAMe

Product name: Doctor's Best SAMe


Enhances your mood, rescues you from the ocean of depression, supports healthy neural metabolism, and also helps with arthritis!


* Pack of 30 tablets

* Contains 400 mg of active SAMe (most important methyl donors in the central nervous system) in each tablet

* S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine

* Involved in numerous biochemical reactions in tissue including the liver, joints and brain

* Required for the biosynthesis of critical neurotransmitters and hormones


S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate), cellulose gel, Methacrylic Acid copolymer, compritol 888ATO, Talc, Triethyl Citrate, Titanium Dioxide, Magnesium stearate, Mannitol, Glycerol Palmitostearate, silica, medium chain triglycerides, sodium starch glycolate and iron oxide.


Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet. Best taken early in the morning on am empty stomach!


Side effects may not occur in every individual who consume SAM-e, so don't these side effects scare you! Also, most of these side effects usually occur due to overdose of the supplement; therefore, it is recommended that you start with a low dosage and increase it gradually, while at the same time closely monitoring its effects (both good and bad) on your body and mind:

a) Gastrointestinal disorder (irregular/loose stools, bloating, stomach cramps, dyspepsia and constipation)

b) anxiety

c) Mania

d) Insomnia

e) Lack of appetite

f) Constipation

e) Nausea

f) Dry mouth

g) Sweating

Source: Wikipedia and personal experience!

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Recommended age:

All Ages


a) Omega-3 fatty acid

b) A daily multi-vitamin

c) Vitamin D3


Below is a summary of the feedback we gathered from the product's ACTUAL customers:


* Great product that succeeded where over-the-counter pain killers failed! I am a 71-year old male who used to suffer from arthritis pain but thanks to SAM-e, for the first time in a couple of years, I slept and woke up from bed without feeling any pain at all! Plus, its mood-claming effect is also a nice plus!

* I love it because it helps to enhance my mood! Thanks to SAM-e, I feel a lot more cheerful and energetic than before! If you have mood or depression issues then definitely go for it!

* Seems like a well-made product that produces the desired results. I would recommend it to anyone who is looking for something beyond the typical "prescription drugs"!

* I have been fighting depression since a long time but after I started taking SAM-e, I realized that the stressful things that used to make me depressed in the past no longer bog me down!

* I am taking it for 8 months now and I can say that SAM-e definitely enhances my mood and helps me deal with stress! On top of that, I am able to think and act more clearly now! Highly recommended!

* This is a great antidepressant that helps with mood enhancement, does not have any side effects, is cheaper than most prescription drugs and can be easily purchased over-the-counter!

* I have been consuming SAM-e for a long time and I can definitely feel the positive effect it has on my mind and body! I would recommend it to anyone who suffers from mood-balancing problems!

* I purchased this product to treat my depression after a recommendation from Dr. OZ, and I can say that I no longer feel depressed! It does not work for everyone though; however, if it is going to work for you, it should show its effect within a week of its regular consumption!


* Product is good, but don't buy from this brand as it seems to be selling dubious supplements which are not potent enough! Try some of the other brands of SAM-e!

* This brand of SAM-e is ineffective compared to the other brands!

* I got stomach cramps (which resulted in frequent tips to the restroom) due to its use. Still, the positive result offered by this product far outweighs the negative side effects!

* I did not feel any mood enhancing effect after consuming the SAM-e sold by this brand. Therefore, I DO NOT recommend THIS brand!

* I take SAM-e regularly, but the effects of this brand's product are not as good as those gotten from the other brands!

* Big waste of money. I bought it after reading so many positive reviews. Oh well…!

* Buyer beware! This vendor seems to be a cheat and fraud!

* This brand's product seems to be counterfeit to me! I purchased SAM-e from another brand and it was terrific!


As I have benefited from its use personally (with varying levels), I cannot recommend SAM-e enough! I used it mainly for my depression, and let us face it, SAM-e's positive effects on mood enchantment is legendary, so do you really need a second opinion on this? However, I would not recommend this particular brand. It seems to me that the positive reviews were mostly left by those who used one or the other brands of SAM-e, and NOT necessarily this particular brand!

If you really want to buy SAM-e, buy the Jarrow Formulas's version. It is probably the most expensive of all the brands available but also the most effective in my own experience, not to mention that I was totally floored by the company's customer service (NOT Amazon.com's)!

Remember, as with anything else in life, you get what you pay for! I can understand if you are a cheapskate with food, gifts, clothing, housing, but if you are a cheapskate even when buying supplements, that too for your own treatment, then shame on you! You pay cheap, you get junk; there's no two ways about it!


Product Dimensions: 1.8 x 3.2 x 6.2 inches

Shipping Weight: 1.6 ounces


None Available


About Doctors Best

We firmly believe in the integration of science research and traditional wisdom as the way that nutritional and herbal supplements will reach their exciting potential.

Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation.

Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace.

Each of our products is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with FDA in accordance with DSHEA regulations.

Traditional wisdom ... up-to-date research ... product quality you can trust ... all the information you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none.

We hope you enjoy your stay at our site and gain the knowledge you wanted. Please contact us if you have any further questions.

Read a letter from our president, Ken Halvorsrude, ensuring the quality of Doctor's Best products.


Snail mail:

Doctor’s Best, Inc.
Attn: Customer Service
197 Avenida La Pata, Suite A
San Clemente, CA 92673

Phone: 1-800-333-6977 Toll Free or 949-498-3628

Best Time to Call: 9am to 5pm PST

Fax: 1-800-754-2036 or Order Fax: 949-498-3952

Email: info [at] drbvitamins [dot] com

Website: http://www.drbvitamins.com/about-us/contact-us.html


Ships from and sold by Amazon.com. Gift-wrap available.

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